Fully synthetic replication of complex real biological cell clusters using a novel cluster-based ‘Rosetta-Routine’ computational modelling process

Bradley Mason; Laura Justham; Liam Whitby; Alison Whitby; Stuart Scott; Samuel Nti; Jon Petzing

doi:10.1371/journal.pcbi.1014280

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Open Access

Peer-reviewed

Research Article

Fully synthetic replication of complex real biological cell clusters using a novel cluster-based ‘Rosetta-Routine’ computational modelling process

Bradley Mason ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: b.mason6@lboro.ac.uk

Affiliation Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom

https://orcid.org/0009-0002-9293-083X

⨯
Laura Justham,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom
⨯
Liam Whitby,

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliation UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, United Kingdom
⨯
Alison Whitby,

Roles Project administration, Resources, Software, Supervision

Affiliation UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, United Kingdom
⨯
Stuart Scott,

Roles Project administration, Resources, Supervision

Affiliation UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, United Kingdom
⨯
Samuel Nti,

Roles Project administration, Resources, Supervision

Affiliation UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, United Kingdom
⨯
Jon Petzing

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom
⨯

Fully synthetic replication of complex real biological cell clusters using a novel cluster-based ‘Rosetta-Routine’ computational modelling process

Bradley Mason,
Laura Justham,
Liam Whitby,
Alison Whitby,
Stuart Scott,
Samuel Nti,
Jon Petzing

Published: May 29, 2026
https://doi.org/10.1371/journal.pcbi.1014280

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