MIAAIM: Multi-omics image integration with dimensional reduction for tissue state mapping

• Joshua M. Hess,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, New York, United States of America

  https://orcid.org/0000-0003-3776-1092

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• Richard K. Dzeng,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America

  https://orcid.org/0000-0002-3664-8883

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• Iulian Ilieş,

  Roles Conceptualization, Methodology, Writing – original draft

  Affiliation Healthcare Systems Engineering Institute, Northeastern University, Boston, Massachusetts, United States of America

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• Denis Schapiro,

  Roles Methodology, Conceptualization

  Affiliations Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard Medical School and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany, Translational Spatial Profiling Center, Heidelberg, Germany

  https://orcid.org/0000-0002-9391-5722

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• John J. Iskra,

  Roles Conceptualization

  Affiliations Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Mathematics, Emory & Henry University, Emory, Virginia, United States of America

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• Divya Mirgh,

  Roles Data curation, Investigation, Resources

  Affiliation Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0009-0001-1507-1616

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• John Nam,

  Roles Data curation, Investigation

  Affiliation Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-9604-0159

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• Erin H. Seeley,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Chemistry, University of Texas, Austin, Texas, United States of America

  https://orcid.org/0000-0002-8000-5754

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• David E. Verrill,

  Roles Investigation

  Affiliation Chemistry and Chemical Biology, Barnett Institute for Chemical & Biological Analysis, Northeastern University, Boston, Massachusetts, United States of America

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• Walid M. Abdelmoula,

  Roles Methodology

  Current address: Invicro, LLC, Boston, Massachusetts, United States of America

  Affiliation Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Michael S. Regan,

  Roles Investigation

  Affiliation Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Georgios Theocharidis,

  Roles Investigation, Methodology

  Affiliation The Rongxiang Xu Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Chin Lee Wu,

  Roles Data curation, Investigation

  Affiliation Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Aristidis Veves,

  Roles Methodology, Investigation

  Affiliation The Rongxiang Xu Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Nathalie Y. R. Agar,

  Roles Investigation, Methodology

  Affiliations Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ann E. Sluder,

  Roles Project administration, Writing – review & editing

  Affiliation Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Mark C. Poznansky ,

  Roles Funding acquisition, Investigation, Supervision, Visualization, Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: mpoznansky@mgh.harvard.edu (MCP); rsirbulescu@mgh.harvard.edu (RFS); patrick_reeves@hms.harvard.edu (PMR)

  ¶☯ MCP, RFS, and PMR contributed equally to and are co-corresponding authors for this manuscript

  Affiliation Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ruxandra F. Sîrbulescu ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mpoznansky@mgh.harvard.edu (MCP); rsirbulescu@mgh.harvard.edu (RFS); patrick_reeves@hms.harvard.edu (PMR)

  ¶☯ MCP, RFS, and PMR contributed equally to and are co-corresponding authors for this manuscript

  Affiliations Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-7905-1713

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•  [ ... ],
• Patrick M. Reeves

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mpoznansky@mgh.harvard.edu (MCP); rsirbulescu@mgh.harvard.edu (RFS); patrick_reeves@hms.harvard.edu (PMR)

  ¶☯ MCP, RFS, and PMR contributed equally to and are co-corresponding authors for this manuscript

  Affiliations Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-8202-0723

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