Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short-range diffusive process

• Thi Nhu Thao Nguyen,

  Roles Conceptualization, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Université Paris Cité, CNRS, MAP5, F-75006 Paris, France, LBMC, ENS de Lyon, CNRS, UMR 5239, Inserm, U1293, Universite Claude Bernard Lyon 1, 46 allee d’Italie F-69364 Lyon, France, Inria, Paris, France

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• Catherine Koering,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation LBMC, ENS de Lyon, CNRS, UMR 5239, Inserm, U1293, Universite Claude Bernard Lyon 1, 46 allee d’Italie F-69364 Lyon, France

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• Elodie Vallin,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation LBMC, ENS de Lyon, CNRS, UMR 5239, Inserm, U1293, Universite Claude Bernard Lyon 1, 46 allee d’Italie F-69364 Lyon, France

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• Sandrine Gonin-Giraud,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation LBMC, ENS de Lyon, CNRS, UMR 5239, Inserm, U1293, Universite Claude Bernard Lyon 1, 46 allee d’Italie F-69364 Lyon, France

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• Laura Broutier,

  Roles Data curation, Writing – review & editing

  Affiliation Childhood Cancer & Cell States Team (C3 Team), LabEx DEVweCAN, Institut Convergence Plascan, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, 69008 Lyon, France

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• Samuel Bernard,

  Roles Software, Writing – review & editing

  Affiliations Inria, Paris, France, Univ Lyon, Université Lyon 1, CNRS UMR5208, Institut Camille Jordan, 43 Blvd du 11 Novembre 1918, Villeurbanne-Cedex F-69622, France

  https://orcid.org/0000-0002-8442-9968

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• Fabien Crauste ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fabien.crauste@math.cnrs.fr

  ¶☯ Joint last co-authors.

  Affiliation Université Paris Cité, CNRS, MAP5, F-75006 Paris, France

  https://orcid.org/0000-0002-9979-9638

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• Olivier Gandrillon

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Joint last co-authors.

  Affiliations LBMC, ENS de Lyon, CNRS, UMR 5239, Inserm, U1293, Universite Claude Bernard Lyon 1, 46 allee d’Italie F-69364 Lyon, France, Inria, Paris, France

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