Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types

• Mingming Zhang,

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Providence Research, Providence Health Care, Vancouver, Canada

  https://orcid.org/0000-0002-8593-7366

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• Young Woong Kim,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Providence Research, Providence Health Care, Vancouver, Canada

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• Chen Xi Yang,

  Roles Methodology, Writing – review & editing

  Affiliation UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada

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• Gail M. Gauvreau,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada

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• J. Mark FitzGerald ,

  Roles Methodology, Resources, Writing – review & editing

  ¶† Deceased

  Affiliation Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada

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• Louis-Philippe Boulet,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Centre de Pneumologie de L’Hopital, Université Laval, Québec City, Québec, Canada

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• Paul M. O’Byrne,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada

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• Scott J. Tebbutt,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Providence Research, Providence Health Care, Vancouver, Canada, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada, PROOF Centre of Excellence, Vancouver, British Columbia, Canada

  https://orcid.org/0000-0002-7908-1581

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• Amrit Singh

  Roles Conceptualization, Data curation, Formal analysis, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: amrit.singh@ubc.ca

  Affiliations Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Providence Research, Providence Health Care, Vancouver, Canada

  https://orcid.org/0000-0002-7475-1646

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