Large-scale paired chain BCR analysis reveals antibody clonal family inference bias and enhances resolution with machine learning

Hao Wang; Kaixuan Wang; Qihang Xu; Linru Cai; Chuanxiang Huang; Linlin Chen; Yunliang Zang; Xihao Hu; Jian Zhang

doi:10.1371/journal.pcbi.1014077

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Open Access

Peer-reviewed

Research Article

Large-scale paired chain BCR analysis reveals antibody clonal family inference bias and enhances resolution with machine learning

Hao Wang ,

Contributed equally to this work with: Hao Wang, Qihang Xu

Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Kaixuan Wang,

Roles Data curation, Formal analysis, Methodology, Resources, Software
⨯
Qihang Xu ,

Contributed equally to this work with: Hao Wang, Qihang Xu

Roles Data curation, Software, Writing – original draft

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Linru Cai,

Roles Formal analysis, Resources

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Chuanxiang Huang,

Roles Visualization

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Linlin Chen,

Roles Formal analysis

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Yunliang Zang,

Roles Formal analysis, Visualization

Affiliation Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
⨯
Xihao Hu,

Roles Visualization

Affiliation GV20 Therapeutics, Cambridge, Massachusetts, United States of America
⨯
Jian Zhang

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: jian_zhang@tju.edu.cn

Affiliations Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China, Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China

https://orcid.org/0000-0002-4966-2086

⨯

Large-scale paired chain BCR analysis reveals antibody clonal family inference bias and enhances resolution with machine learning

Hao Wang,
Kaixuan Wang,
Qihang Xu,
Linru Cai,
Chuanxiang Huang,
Linlin Chen,
Yunliang Zang,
Xihao Hu,
Jian Zhang

Published: March 11, 2026
https://doi.org/10.1371/journal.pcbi.1014077

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B cells
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Antibodies
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Immune response
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Insertion mutation
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