Interpretable integration of unpaired multi-omics for Alzheimer’s diagnosis via cross-modal transformer reconstruction

• Kai Liao ,

  Contributed equally to this work with: Kai Liao, Danfeng Du

  Roles Conceptualization, Data curation

  Affiliations The Central Laboratory of Birth Defects Prevention and Control, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China, Ningbo Key Laboratory for the Prevention and Treatment of Embryogenic Diseases, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China, Ningbo Key Laboratory of Genomic Medicine and Birth Defects Prevention, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, China

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• Danfeng Du ,

  Contributed equally to this work with: Kai Liao, Danfeng Du

  Roles Investigation, Methodology

  Affiliation Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

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• Jiawei Li,

  Roles Data curation, Methodology, Visualization

  Affiliation School of Computer Science, Northwestern Polytechnical University, Shaanxi, China

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• Jian Huang,

  Roles Software, Supervision, Validation

  Affiliation College of Computer Science, Chongqing University, Chongqing, China

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• Xiaodan Fan,

  Roles Validation, Visualization, Writing – original draft

  Affiliation The Central Laboratory of Birth Defects Prevention and Control, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China

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• Changshui Chen,

  Roles Data curation, Formal analysis

  Affiliation Ningbo Key Laboratory for the Prevention and Treatment of Embryogenic Diseases, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China

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• Shanshan Wu,

  Roles Conceptualization, Resources, Validation

  Affiliation Ningbo Key Laboratory of Genomic Medicine and Birth Defects Prevention, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China

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• Bowei Yan ,

  Roles Conceptualization, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: 22111510005@m.fudan.edu.cn, boweiyan2020@gmail.com (BY); lihaibo-775@163.com (HL)

  Affiliation Institutes of Biomedical Sciences, Fudan University, Shanghai, China

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• Haibo Li

  Roles Writing – original draft, Writing – review & editing

  * E-mail: 22111510005@m.fudan.edu.cn, boweiyan2020@gmail.com (BY); lihaibo-775@163.com (HL)

  Affiliations The Central Laboratory of Birth Defects Prevention and Control, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China, Ningbo Key Laboratory for the Prevention and Treatment of Embryogenic Diseases, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China, Ningbo Key Laboratory of Genomic Medicine and Birth Defects Prevention, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, China

  https://orcid.org/0009-0006-8353-579X

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