Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks

• Bao-Dan Zhang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations College of Agriculture and Biological Science, Dali University, Dali, China, Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University, Dali, China, Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Developmentof Yunnan Province, Dali University, Dali, China

  ⨯
• De-Rui Zhao,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Software, Validation

  Affiliations College of Agriculture and Biological Science, Dali University, Dali, China, Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University, Dali, China, Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Developmentof Yunnan Province, Dali University, Dali, China

  ⨯
• Meng-Ting Liu,

  Roles Conceptualization, Methodology, Resources, Supervision

  Affiliations College of Agriculture and Biological Science, Dali University, Dali, China, Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University, Dali, China

  ⨯
• Li-Quan Yang ,

  Roles Conceptualization, Resources, Supervision

  * E-mail: ylqbioinfo@dali.edu.cn (L-QY); pengsang@dali.edu.cn (PS)

  Affiliations College of Agriculture and Biological Science, Dali University, Dali, China, Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University, Dali, China, Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Developmentof Yunnan Province, Dali University, Dali, China

  ⨯
• Peng Sang

  Roles Conceptualization, Investigation, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: ylqbioinfo@dali.edu.cn (L-QY); pengsang@dali.edu.cn (PS)

  Affiliations College of Agriculture and Biological Science, Dali University, Dali, China, Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University, Dali, China, Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Developmentof Yunnan Province, Dali University, Dali, China

  https://orcid.org/0000-0002-8556-2461

  ⨯