FKSUDDAPre: A drug–disease association prediction framework based on F-TEST feature selection and AMDKSU resampling with interpretability analysis

Yun Zuo; Chenyi Zhang; Ge Hua; Qiao Ning; Xiangrong Liu; Xiangxiang Zeng; Zhaohong Deng

doi:10.1371/journal.pcbi.1013947

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Open Access

Peer-reviewed

Research Article

FKSUDDAPre: A drug–disease association prediction framework based on F-TEST feature selection and AMDKSU resampling with interpretability analysis

Yun Zuo ,

Roles Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

* E-mail: zuoyun@jiangnan.edu.cn

Affiliation School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Wuxi, China

https://orcid.org/0009-0003-4021-3836

⨯
Chenyi Zhang,

Roles Data curation, Methodology, Writing – original draft

Affiliation School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Wuxi, China

https://orcid.org/0009-0008-9691-5948

⨯
Ge Hua,

Roles Methodology, Validation

Affiliation School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Wuxi, China
⨯
Qiao Ning,

Roles Writing – review & editing

Affiliation School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Wuxi, China
⨯
Xiangrong Liu,

Roles Writing – review & editing

Affiliation Department of Computer Science and Technology, National Institute for Data Science in Health and Medicine, Xiamen Key Laboratory of Intelligent Storage and Computing, Xiamen University, Xiamen, China
⨯
Xiangxiang Zeng,

Roles Writing – review & editing

Affiliation School of Information Science and Engineering, Hunan University, Yuelu District, Changsha, China
⨯
Zhaohong Deng

Roles Writing – review & editing

Affiliation School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Wuxi, China
⨯

FKSUDDAPre: A drug–disease association prediction framework based on F-TEST feature selection and AMDKSU resampling with interpretability analysis

Yun Zuo,
Chenyi Zhang,
Ge Hua,
Qiao Ning,
Xiangrong Liu,
Xiangxiang Zeng,
Zhaohong Deng

Published: February 5, 2026
https://doi.org/10.1371/journal.pcbi.1013947

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