Synthetic data enables human-grade microtubule analysis with foundation models for segmentation

Mario Koddenbrock; Justus Westerhoff; Dominik Fachet; Simone Reber; Felix A. Gers; Erik Rodner

doi:10.1371/journal.pcbi.1013901

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Open Access

Peer-reviewed

Research Article

Synthetic data enables human-grade microtubule analysis with foundation models for segmentation

Mario Koddenbrock ,

Contributed equally to this work with: Mario Koddenbrock, Justus Westerhoff

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mario.koddenbrock@htw-berlin.de (MK); justus.westerhoff@bht-berlin.de (JW); erik.rodner@htw-berlin.de (ER)

Affiliation KI Werkstatt, Hochschule für Technik und Wirtschaft Berlin (HTW), Berlin, Germany

https://orcid.org/0000-0003-3327-7404

⨯
Justus Westerhoff ,

Contributed equally to this work with: Mario Koddenbrock, Justus Westerhoff

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mario.koddenbrock@htw-berlin.de (MK); justus.westerhoff@bht-berlin.de (JW); erik.rodner@htw-berlin.de (ER)

Affiliation Berliner Hochschule für Technik (BHT), Berlin, Germany

https://orcid.org/0009-0002-0077-8333

⨯
Dominik Fachet,

Roles Data curation, Resources, Writing – original draft

Affiliation Max Planck Institute for Infection Biology, Berlin,‌‌ Germany

https://orcid.org/0000-0003-4321-9304

⨯
Simone Reber,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Berliner Hochschule für Technik (BHT), Berlin, Germany, Max Planck Institute for Infection Biology, Berlin,‌‌ Germany
⨯
Felix A. Gers,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Berliner Hochschule für Technik (BHT), Berlin, Germany
⨯
Erik Rodner

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: mario.koddenbrock@htw-berlin.de (MK); justus.westerhoff@bht-berlin.de (JW); erik.rodner@htw-berlin.de (ER)

Affiliations KI Werkstatt, Hochschule für Technik und Wirtschaft Berlin (HTW), Berlin, Germany, Merantix Momentum GmbH, Berlin, ‌‌Germany
⨯

Synthetic data enables human-grade microtubule analysis with foundation models for segmentation

Mario Koddenbrock,
Justus Westerhoff,
Dominik Fachet,
Simone Reber,
Felix A. Gers,
Erik Rodner

Published: May 5, 2026
https://doi.org/10.1371/journal.pcbi.1013901

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