DDGWizard: Integration of feature calculation resources for analysis and prediction of changes in protein thermostability upon point mutations

Mingkai Wang; Khaled Jumah; Qun Shao; Katarzyna Kamieniecka; Yihan Liu; Krzysztof Poterlowicz

doi:10.1371/journal.pcbi.1013783

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Open Access

Peer-reviewed

Research Article

DDGWizard: Integration of feature calculation resources for analysis and prediction of changes in protein thermostability upon point mutations

Mingkai Wang,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

Affiliations Institute of Health and Social Care, University of Bradford, Bradford, United Kingdom, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China
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Khaled Jumah,

Roles Formal analysis, Methodology, Validation, Writing – review & editing

Affiliation Institute of Health and Social Care, University of Bradford, Bradford, United Kingdom
⨯
Qun Shao,

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Institute of Health and Social Care, University of Bradford, Bradford, United Kingdom
⨯
Katarzyna Kamieniecka,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Institute of Health and Social Care, University of Bradford, Bradford, United Kingdom
⨯
Yihan Liu ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: lyh@tust.edu.cn (YL); K.Poterlowicz1@bradford.ac.uk (KP)

Affiliation Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China
⨯
Krzysztof Poterlowicz

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: lyh@tust.edu.cn (YL); K.Poterlowicz1@bradford.ac.uk (KP)

Affiliation Institute of Health and Social Care, University of Bradford, Bradford, United Kingdom

https://orcid.org/0000-0001-6173-5674

⨯

DDGWizard: Integration of feature calculation resources for analysis and prediction of changes in protein thermostability upon point mutations

Mingkai Wang,
Khaled Jumah,
Qun Shao,
Katarzyna Kamieniecka,
Yihan Liu,
Krzysztof Poterlowicz

Published: December 1, 2025
https://doi.org/10.1371/journal.pcbi.1013783

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Forecasting
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Reverse mutation
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Protein structure
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Mutation databases
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Amino acid analysis
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Amino acid substitution
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Protein structure prediction
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