OneProt: Towards multi-modal protein foundation models via latent space alignment of sequence, structure, binding sites and text encoders

• Klemens Flöge,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft

  Affiliations PriorLabs, Berlin, Germany, Helmholtz AI, Munich, Germany

  ⨯
• Srisruthi Udayakumar,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization

  Affiliation Independent Researcher, Coimbatore, Tamil Nadu, India

  ⨯
• Johanna Sommer,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliations School of Computation, Information and Technology, Technical University of Munich, Garching, Germany, Munich Data Science Institute, Technical University of Munich, Garching, Germany

  ⨯
• Marie Piraud,

  Roles Funding acquisition, Resources, Supervision, Writing – original draft

  Affiliation Helmholtz Munich, Neuherberg, Germany

  ⨯
• Stefan Kesselheim,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – original draft

  Affiliations Helmholtz AI, Munich, Germany, Jülich Supercomputing Centre, Forschungszentrum Jülich, Jülich, Germany

  ⨯
• Vincent Fortuin,

  Roles Funding acquisition, Supervision, Writing – original draft

  Affiliations Helmholtz AI, Munich, Germany, Munich Center for Machine Learning, Munich, Germany

  ⨯
• Stephan Günnemann,

  Roles Funding acquisition, Supervision, Writing – original draft

  Affiliations School of Computation, Information and Technology, Technical University of Munich, Garching, Germany, Munich Data Science Institute, Technical University of Munich, Garching, Germany, Munich Center for Machine Learning, Munich, Germany

  ⨯
• Karel J. van der Weg,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich, Jülich, Germany, Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

  ⨯
• Holger Gohlke,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich, Jülich, Germany, Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

  https://orcid.org/0000-0001-8613-1447

  ⨯
• Erinc Merdivan,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

  Affiliation Helmholtz Munich, Neuherberg, Germany

  ⨯
• Alina Bazarova

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: al.bazarova@fz-juelich.de

  Affiliations Helmholtz AI, Munich, Germany, Jülich Supercomputing Centre, Forschungszentrum Jülich, Jülich, Germany

  https://orcid.org/0000-0001-8874-1783

  ⨯