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Open Access
Peer-reviewed
Methods
Inferring pathway activity from single-cell and spatial transcriptomics data with PaaSc
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Xiqi Liao ,
Contributed equally to this work with: Xiqi Liao, Yuyang Hong, Yan Feng
Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China
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Yuyang Hong ,
Contributed equally to this work with: Xiqi Liao, Yuyang Hong, Yan Feng
Roles Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China
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Yan Feng ,
Contributed equally to this work with: Xiqi Liao, Yuyang Hong, Yan Feng
Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China
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Henghui Li,
Roles Methodology, Software, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China
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Hai Fang,
Roles Resources, Supervision, Writing – original draft, Writing – review & editing
Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Jiantao Shi
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jtshi@sibcb.ac.cn
Affiliation Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China
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Inferring pathway activity from single-cell and spatial transcriptomics data with PaaSc
- Xiqi Liao,
- Yuyang Hong,
- Yan Feng,
- Henghui Li,
- Hai Fang,
- Jiantao Shi
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- Published: November 10, 2025
- https://doi.org/10.1371/journal.pcbi.1013666