Biphasic effects on human atrial arrhythmogenicity of L-type calcium channel mutations associated with a Brugada/Short QT overlap syndrome - insights from a multiscale simulation study

• Yirong Xiang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester, United Kingdom

  https://orcid.org/0000-0001-6887-5610

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• Jules C. Hancox,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliations Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester, United Kingdom, Cardiovascular Research Laboratories, Bristol Medical School (THS), Biomedical Sciences Building, University Walk, Bristol, United Kingdom

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• Henggui Zhang

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

  * E-mail: henggui.zhang@manchester.ac.uk

  Affiliations Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester, United Kingdom, State Key Laboratory of Digital Medical Engineering, School of Instrument Science and Engineering, Southeast University, Nanjing, China, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China

  https://orcid.org/0000-0002-0863-5807

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