Analytical and computational solution for the estimation of SNP-heritability in biobank-scale and distributed datasets

• Guo-An Qi ,

  Contributed equally to this work with: Guo-An Qi, Qi-Xin Zhang

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization

  Affiliations Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, China, Center for Laboratory Medicine, Department of Genetic and Genomic Medicine, and Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China

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• Qi-Xin Zhang ,

  Contributed equally to this work with: Guo-An Qi, Qi-Xin Zhang

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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• Jingyu Kang,

  Roles Methodology, Validation

  Affiliation School of Mathematics and Statistics and Research Institute of Mathematical Sciences (RIMS), Jiangsu Provincial Key Laboratory of Educational Big Data Science and Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, China

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• Tianyuan Li,

  Roles Methodology

  Affiliation School of Mathematics and Statistics and Research Institute of Mathematical Sciences (RIMS), Jiangsu Provincial Key Laboratory of Educational Big Data Science and Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, China

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• Xiyun Xu,

  Roles Investigation, Validation

  Affiliation School of Mathematics and Statistics and Research Institute of Mathematical Sciences (RIMS), Jiangsu Provincial Key Laboratory of Educational Big Data Science and Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, China

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• Zhe Zhang,

  Roles Funding acquisition, Investigation, Validation

  Affiliation Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China

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• Zhe Fan,

  Roles Formal analysis

  Affiliation School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China

  https://orcid.org/0009-0003-1510-0899

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• Siyang Liu,

  Roles Funding acquisition, Investigation, Supervision

  Affiliation School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China

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• Guo-Bo Chen

  Roles Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Visualization, Writing – original draft

  * E-mail: chenguobo@gmail.com

  Affiliations Center for Laboratory Medicine, Department of Genetic and Genomic Medicine, and Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, China

  https://orcid.org/0000-0001-5475-8237

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