Harmony-based data integration for distributed single-cell multi-omics data

Ruizhi Yuan; Ziqi Rong; Haoran Hu; Tianhao Liu; Shiyue Tao; Wei Chen; Lu Tang

doi:10.1371/journal.pcbi.1013526

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Peer-reviewed

Harmony-based data integration for distributed single-cell multi-omics data

Ruizhi Yuan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0009-0000-8996-8963

⨯
Ziqi Rong,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Haoran Hu,

Roles Data curation, Writing – review & editing

Affiliation Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0003-3619-2852

⨯
Tianhao Liu,

Roles Data curation, Writing – review & editing

Affiliation Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Shiyue Tao,

Roles Data curation, Writing – review & editing

Affiliation Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Wei Chen ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wei.chen@pitt.edu (WC); lutang@pitt.edu (LT)

Affiliations Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Lu Tang

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wei.chen@pitt.edu (WC); lutang@pitt.edu (LT)

Affiliation Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0001-6143-9314

⨯

Harmony-based data integration for distributed single-cell multi-omics data

Ruizhi Yuan,
Ziqi Rong,
Haoran Hu,
Tianhao Liu,
Shiyue Tao,
Wei Chen,
Lu Tang

Published: September 30, 2025
https://doi.org/10.1371/journal.pcbi.1013526

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