Double-CRISPR Knockout Simulation (DKOsim): A Monte-Carlo randomization system to model cell growth behavior and infer the optimal library design for growth-based double knockout screens

• Yue Gu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  https://orcid.org/0000-0002-9642-0338

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• Traver Hart,

  Roles Investigation, Resources, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Luis Leon-Novelo ,

  Roles Data curation, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: Jshen8@mdanderson.org (JPS); Luis.G.LeonNovelo@uth.tmc.edu (LLN)

  Affiliation Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• John Paul Shen

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: Jshen8@mdanderson.org (JPS); Luis.G.LeonNovelo@uth.tmc.edu (LLN)

  Affiliation Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  https://orcid.org/0000-0003-4588-2775

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