A comparative computational analysis of IFN-alpha pharmacokinetics and its induced cellular response in mice and humans

• Priyata Kalra ,

  Contributed equally to this work with: Priyata Kalra, Bastian Kister

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

  Current Address: Simulations Plus, Lancaster, California, United States of America.

  Affiliation Department of Modelling of Biological Processes, COS/BioQuant, Heidelberg University, Heidelberg, Germany

  ⨯
• Bastian Kister ,

  Contributed equally to this work with: Priyata Kalra, Bastian Kister

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Conceptualization

  Current Address: Pharmetheus AB, Uppsala, Sweden.

  Affiliations Department of Modelling of Biological Processes, COS/BioQuant, Heidelberg University, Heidelberg, Germany, Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany

  ⨯
• Rebekka Fendt,

  Roles Investigation, Writing – review & editing, Formal analysis

  Affiliations Department of Modelling of Biological Processes, COS/BioQuant, Heidelberg University, Heidelberg, Germany, Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany

  ⨯
• Mario Köster,

  Roles Resources, Writing – review & editing, Investigation

  Affiliation Model System for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany

  ⨯
• Julia Pulverer,

  Roles Resources, Writing – review & editing, Investigation

  Affiliation Model System for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany

  ⨯
• Sven Sahle,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Modelling of Biological Processes, COS/BioQuant, Heidelberg University, Heidelberg, Germany

  ⨯
• Lars Kuepfer ,

  Roles Formal analysis, Supervision, Writing – original draft, Conceptualization

  * E-mail: lkuepfer@ukaachen.de (LK); ursula.kummer@bioquant.uni-heidelberg.de (UK)

  Affiliation Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany

  https://orcid.org/0000-0002-8741-7786

  ⨯
• Ursula Kummer

  Roles Conceptualization, Formal analysis, Supervision, Visualization, Writing – original draft

  * E-mail: lkuepfer@ukaachen.de (LK); ursula.kummer@bioquant.uni-heidelberg.de (UK)

  Affiliation Department of Modelling of Biological Processes, COS/BioQuant, Heidelberg University, Heidelberg, Germany

  ⨯