Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions

• William Jeffries,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Bryan M. Delfing,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Xavier E. Laracuente,

  Roles Methodology, Software, Writing – review & editing

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Xingyu Luo,

  Roles Writing – review & editing

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Audrey Olson,

  Roles Writing – review & editing

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Kenneth W. Foreman,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America

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• Kyung Hyeon Lee,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America, Center for Molecular Engineering, George Mason University, Manassas, Virginia, United States of America

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• Greg Petruncio,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America, Center for Molecular Engineering, George Mason University, Manassas, Virginia, United States of America

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• Vito De Benedictis,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America, Center for Molecular Engineering, George Mason University, Manassas, Virginia, United States of America

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• Mikell Paige,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America, Center for Molecular Engineering, George Mason University, Manassas, Virginia, United States of America

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• Kylene Kehn-Hall,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-Borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Christopher Lockhart,

  Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

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• Dmitri K. Klimov

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: dklimov@gmu.edu

  Affiliation School of Systems Biology, George Mason University, Manassas, Virginia, United States of America

  https://orcid.org/0000-0002-2893-867X

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