Free energy perturbations in enzyme kinetic models reveal cryptic epistasis

• Karol Buda ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: karol.buda@msl.ubc.ca (KB); tokuriki@msl.ubc.ca (NT)

  Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

  https://orcid.org/0000-0001-9312-0498

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• Nobuhiko Tokuriki

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  * E-mail: karol.buda@msl.ubc.ca (KB); tokuriki@msl.ubc.ca (NT)

  Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

  https://orcid.org/0000-0002-8235-1829

  ⨯