Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: In silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain

• Monica Sacco ,

  Contributed equally to this work with: Monica Sacco, Stefano Lancellotti

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica S. Cuore, Facoltà di Medicina e Chirurgia “Agostino Gemelli”, Roma, Italy

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• Stefano Lancellotti ,

  Contributed equally to this work with: Monica Sacco, Stefano Lancellotti

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario “A. Gemell” IRCCS, Roma, Italy

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• Antonietta Ferretti,

  Roles Visualization, Writing – review & editing

  Affiliation Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario “A. Gemell” IRCCS, Roma, Italy

  https://orcid.org/0000-0001-7115-8743

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• Maria Basso,

  Roles Visualization, Writing – review & editing

  Affiliation Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario “A. Gemell” IRCCS, Roma, Italy

  ⨯
• Leonardo Di Gennaro,

  Roles Writing – review & editing

  Affiliation Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario “A. Gemell” IRCCS, Roma, Italy

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• Giancarlo Castaman ,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  ¶‡ These authors are co-senior authors on this work.

  Affiliation Centro Malattie Emorragiche e della Coagulazione, Dipartimento di Oncologia, Ospedale Universitario “Careggi”, Firenze, Italy

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• Raimondo De Cristofaro

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: raimondo.decristofaro@unicatt.it

  ¶‡ These authors are co-senior authors on this work.

  Affiliations Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica S. Cuore, Facoltà di Medicina e Chirurgia “Agostino Gemelli”, Roma, Italy, Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario “A. Gemell” IRCCS, Roma, Italy

  https://orcid.org/0000-0002-8066-8849

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