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Open Access
Peer-reviewed
Methods
MRDtarget: A heuristic Gaussian approach for optimizing targeted capture regions to enhance Minimal Residual Disease detection
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Xuwen Wang,
Roles Formal analysis, Investigation, Visualization, Writing – original draft
Affiliations Department of Respiratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China, School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
⨯ -
Yanfang Guan,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliations School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China, Geneplus-Beijing, Beijing, China
⨯ -
Wei Gao,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Geneplus-Beijing, Beijing, China
⨯ -
Xin Lai,
Roles Resources, Writing – review & editing
Affiliations School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
⨯ - Wuqiang Cao,
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Xiaoyan Zhu,
Roles Resources
Affiliations School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
⨯ - Xiaoling Zeng,
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Yuqian Liu,
Roles Resources
Affiliations School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
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Shenjie Wang,
Roles Data curation, Formal analysis
Affiliations Department of Respiratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China, School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
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Ruoyu Liu,
Roles Data curation, Formal analysis
Affiliations Department of Respiratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China, School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
⨯ - Xin Yi,
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Shuanying Yang ,
Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing
* E-mail: yangshuanying@xjtu.edu.cn (SY); wangjiayin@mail.xjtu.edu.cn (JW)
Affiliation Department of Respiratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
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Jiayin Wang
Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing
* E-mail: yangshuanying@xjtu.edu.cn (SY); wangjiayin@mail.xjtu.edu.cn (JW)
Affiliations School of Computer Science and Technology, Xi’an Jiaotong University, Xi’an, China, Shaanxi Engineering Research Center of Medical and Health Big Data, Xi’an Jiaotong University, Xi’an, China
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MRDtarget: A heuristic Gaussian approach for optimizing targeted capture regions to enhance Minimal Residual Disease detection
- Xuwen Wang,
- Yanfang Guan,
- Wei Gao,
- Xin Lai,
- Wuqiang Cao,
- Xiaoyan Zhu,
- Xiaoling Zeng,
- Yuqian Liu,
- Shenjie Wang,
- Ruoyu Liu
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- Published: September 17, 2025
- https://doi.org/10.1371/journal.pcbi.1013443