Leveraging structure-informed machine learning for fast steric zipper propensity prediction across whole proteomes

• Samantha Zink ,

  Contributed equally to this work with: Samantha Zink, Songrong Qu

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics, STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America

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• Songrong Qu ,

  Contributed equally to this work with: Samantha Zink, Songrong Qu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics, STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America

  https://orcid.org/0000-0002-1179-6468

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• Thomas Holton,

  Roles Project administration, Resources, Software, Validation, Visualization, Writing – review & editing

  Affiliation Departments of Chemistry and Biochemistry and Biological Chemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, California, United States of America

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• Eesha Shankar,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics, STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America

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• Paulina Stanley,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics, STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America

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• David S. Eisenberg,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Departments of Chemistry and Biochemistry and Biological Chemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, California, United States of America

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• Michael R. Sawaya ,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jrodriguez@mbi.ucla.edu (JAR); sawaya@mbi.ucla.edu (MRS)

  Affiliation Departments of Chemistry and Biochemistry and Biological Chemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, California, United States of America

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• Jose A. Rodriguez

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jrodriguez@mbi.ucla.edu (JAR); sawaya@mbi.ucla.edu (MRS)

  Affiliation Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics, STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America

  https://orcid.org/0000-0002-0248-4964

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