Mechanistically informed machine learning links non-canonical TCA cycle activity to Warburg metabolism and hallmarks of malignancy

• Lihao Lin,

  Roles Conceptualization, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

  https://orcid.org/0009-0005-4962-8370

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• Francesco Lapi,

  Roles Investigation, Methodology, Software

  Affiliation Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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• Bruno Giovanni Galuzzi,

  Roles Methodology, Software

  Affiliations SYSBIO Centre of Systems Biology/ ISBE.IT, Milan, Italy, Institute of Bioimaging and Complex Biological Systems, Segrate, Italy, National Biodiversity Future Center, Palermo, Italy

  https://orcid.org/0000-0002-8518-5352

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• Marco Vanoni,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy, SYSBIO Centre of Systems Biology/ ISBE.IT, Milan, Italy

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• Lilia Alberghina,

  Roles Conceptualization, Funding acquisition

  Affiliations Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy, SYSBIO Centre of Systems Biology/ ISBE.IT, Milan, Italy

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• Chiara Damiani

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  * E-mail: chiara.damiani@unimib.it

  Affiliations Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy, SYSBIO Centre of Systems Biology/ ISBE.IT, Milan, Italy

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