An alignment-free strategy for circulating tumor DNA detection and tumor fraction estimation from whole-genome sequencing data

• Carmen Oroperv ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: besenbacher@clin.au.dk (SB); cla@clin.au.dk (CLA); caor@clin.au.dk (CO)

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

  https://orcid.org/0009-0008-7199-896X

  ⨯
• Amanda Frydendahl,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

  ⨯
• Tenna Vesterman Henriksen,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

  ⨯
• Giovanni Santacatterina,

  Roles Methodology, Software, Visualization, Writing – review & editing

  Affiliation Department of Mathematics, Informatics and Geosciences, University of Trieste, Italy

  ⨯
• Alice Antonello,

  Roles Methodology, Software, Visualization, Writing – review & editing

  Affiliation Department of Mathematics, Informatics and Geosciences, University of Trieste, Italy

  ⨯
• Nicola Calonaci,

  Roles Methodology, Software, Visualization, Writing – review & editing

  Affiliation Department of Mathematics, Informatics and Geosciences, University of Trieste, Italy

  ⨯
• Mads Heilskov Rasmussen,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

  ⨯
• Giulio Caravagna,

  Roles Methodology, Software, Supervision, Writing – review & editing

  Affiliation Department of Mathematics, Informatics and Geosciences, University of Trieste, Italy

  ⨯
• Claus Lindbjerg Andersen ,

  Roles Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: besenbacher@clin.au.dk (SB); cla@clin.au.dk (CLA); caor@clin.au.dk (CO)

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

  https://orcid.org/0000-0002-7406-2103

  ⨯
• Søren Besenbacher ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: besenbacher@clin.au.dk (SB); cla@clin.au.dk (CLA); caor@clin.au.dk (CO)

  Affiliations Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark

  https://orcid.org/0000-0003-1455-1738

  ⨯
• IMPROVE-consortia

  ¶Membership of the IMPROVE-consortia is provided in the Acknowledgments.

  ⨯