Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns

• Bengi Ruken Yavuz,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Cancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland, United States of America

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• Ugur Sahin,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey

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• Hyunbum Jang,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Cancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland, United States of America, Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

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• Ruth Nussinov ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: ntuncbag@ku.edu.tr (NT); nussinor@mail.nih.gov (RN)

  Affiliations Cancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland, United States of America, Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

  https://orcid.org/0000-0002-8115-6415

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• Nurcan Tuncbag

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ntuncbag@ku.edu.tr (NT); nussinor@mail.nih.gov (RN)

  Affiliations Department of Chemical and Biological Engineering, College of Engineering, Koç University, Istanbul, Turkey, School of Medicine, Koç University, Istanbul, Turkey, Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey

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