A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens

Weheliye H. Weheliye; Javier Rodriguez; Luigi Feriani; Avelino Javer; Virginie Uhlmann; André E. X. Brown

doi:10.1371/journal.pcbi.1013345

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Peer-reviewed

A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens

Weheliye H. Weheliye,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliations MRC Laboratory of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom
⨯
Javier Rodriguez,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization

Affiliations MRC Laboratory of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom
⨯
Luigi Feriani,

Roles Data curation, Investigation, Validation, Visualization

address: Australian Synchrotron - ANSTO, Melbourne, Australia

Affiliations MRC Laboratory of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom

https://orcid.org/0000-0001-6349-7833

⨯
Avelino Javer,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Current address: Apheris, Berlin, Germany

Affiliations MRC Laboratory of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom
⨯
Virginie Uhlmann,

Roles Conceptualization, Investigation, Methodology, Software, Supervision, Visualization

Affiliation European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom
⨯
André E. X. Brown

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: andre.brown@imperial.ac.uk

Affiliations MRC Laboratory of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-1324-8764

⨯

A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens

Weheliye H. Weheliye,
Javier Rodriguez,
Luigi Feriani,
Avelino Javer,
Virginie Uhlmann,
André E. X. Brown

Published: August 8, 2025
https://doi.org/10.1371/journal.pcbi.1013345

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