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Open Access
Peer-reviewed
Research Article
A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations
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Marco Vanoni ,
Contributed equally to this work with: Marco Vanoni, Pasquale Palumbo
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
* E-mail: marco.vanoni@unimib.it (MV); lilia.alberghina@unimib.it (LA)
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Pasquale Palumbo ,
Contributed equally to this work with: Marco Vanoni, Pasquale Palumbo
Roles Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Federico Papa,
Roles Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, IASI-CNR, Rome, Italy
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Stefano Busti,
Roles Investigation, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Laura Gotti,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Meike Wortel,
Roles Investigation
Affiliation University of Amsterdam, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands
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Bas Teusink,
Roles Conceptualization, Writing – original draft
Affiliation Vrije Universiteit Amsterdam, Systems Biology Lab, AIMMS, Amsterdam, The Netherlands
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Ivan Orlandi,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Alex Pessina,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Cristina Airoldi,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Luca Brambilla,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Marina Vai,
Roles Investigation
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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Lilia Alberghina
Roles Conceptualization, Writing – original draft, Writing – review & editing
* E-mail: marco.vanoni@unimib.it (MV); lilia.alberghina@unimib.it (LA)
Affiliations SYSBIO Centre for Systems Biology, Milan, Italy, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations
- Marco Vanoni,
- Pasquale Palumbo,
- Federico Papa,
- Stefano Busti,
- Laura Gotti,
- Meike Wortel,
- Bas Teusink,
- Ivan Orlandi,
- Alex Pessina,
- Cristina Airoldi
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- Published: July 21, 2025
- https://doi.org/10.1371/journal.pcbi.1013296