How cells tame noise while maintaining ultrasensitive transcriptional responses

Eui Min Jeong; Chang Yoon Chung; Jae Kyoung Kim

doi:10.1371/journal.pcbi.1013217

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Open Access

Peer-reviewed

Research Article

How cells tame noise while maintaining ultrasensitive transcriptional responses

Eui Min Jeong ,

Contributed equally to this work with: Eui Min Jeong, Chang Yoon Chung

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: wjddmlals11@inha.ac.kr, jaekkim@kaist.ac.kr

Affiliations Department of Data Science, Inha University, Incheon, Republic of Korea, Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea
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Chang Yoon Chung ,

Contributed equally to this work with: Eui Min Jeong, Chang Yoon Chung

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Department of Mathematics and Statistics, Université de Montréal, Montréal, Québec, Canada
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Jae Kyoung Kim

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: wjddmlals11@inha.ac.kr, jaekkim@kaist.ac.kr

Current Address: Department of Mathematical Sciences, KAIST, 291, Daehak-ro Yuseong-gu, Daejeon Republic of Korea

Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea, Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea, Graduate School of Data Science, KAIST, Daejeon, Republic of Korea

https://orcid.org/0000-0001-7842-2172

⨯

How cells tame noise while maintaining ultrasensitive transcriptional responses

Eui Min Jeong,
Chang Yoon Chung,
Jae Kyoung Kim

Published: December 11, 2025
https://doi.org/10.1371/journal.pcbi.1013217

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DNA transcription
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Messenger RNA
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Transcriptional control
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Gene regulation
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Transcription factors
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DNA-binding proteins
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Circadian oscillators
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Noise reduction
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