Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model

Alexander P. Browning; Rebecca M. Crossley; Chiara Villa; Philip K. Maini; Adrianne L. Jenner; Tyler Cassidy; Sara Hamis

doi:10.1371/journal.pcbi.1013202

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Open Access

Peer-reviewed

Research Article

Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model

Alexander P. Browning ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: alex.browning@unimelb.edu.au

Affiliations School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia, Mathematical Institute, University of Oxford, Oxford, United Kingdom

https://orcid.org/0000-0002-8753-1538

⨯
Rebecca M. Crossley,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Mathematical Institute, University of Oxford, Oxford, United Kingdom

https://orcid.org/0000-0001-7342-0207

⨯
Chiara Villa,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Sorbonne Université, CNRS, Université de Paris, Inria, Laboratoire Jacques-Louis Lions UMR, Paris, France, Université Paris-Saclay, Inria, Centre Inria de Saclay, Palaiseau, France

https://orcid.org/0000-0003-3127-0532

⨯
Philip K. Maini,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Mathematical Institute, University of Oxford, Oxford, United Kingdom

https://orcid.org/0000-0002-0146-9164

⨯
Adrianne L. Jenner,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
⨯
Tyler Cassidy,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation School of Mathematics, University of Leeds, Leeds, United Kingdom
⨯
Sara Hamis

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Information Technology, Uppsala University, Uppsala, Sweden
⨯

Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model

Alexander P. Browning,
Rebecca M. Crossley,
Chiara Villa,
Philip K. Maini,
Adrianne L. Jenner,
Tyler Cassidy,
Sara Hamis

Published: June 24, 2025
https://doi.org/10.1371/journal.pcbi.1013202

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