Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk

• Jiaqi Hu ,

  Contributed equally to this work with: Jiaqi Hu, Yixuan Ye

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to the paper.

  Affiliation Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0002-6317-7730

  ⨯
• Yixuan Ye ,

  Contributed equally to this work with: Jiaqi Hu, Yixuan Ye

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to the paper.

  Affiliation Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

  ⨯
• Chi Zhang,

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0002-2682-4142

  ⨯
• Yunfeng Ruan,

  Roles Methodology

  Affiliations Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Pradeep Natarajan,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliations Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Hongyu Zhao

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: hongyu.zhao@yale.edu

  Affiliations Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0003-1195-9607

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