Explainable AI-driven diagnosis model for early glaucoma detection using grey-wolf optimized extreme learning machine approach

Debendra Muduli; Santosh Kumar Sharma; Sujata Dash; Bernardo Lemos; Saurav Mallik

doi:10.1371/journal.pcbi.1013139

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Open Access

Peer-reviewed

Research Article

Explainable AI-driven diagnosis model for early glaucoma detection using grey-wolf optimized extreme learning machine approach

Debendra Muduli,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Visualization, Writing – original draft

Affiliation Department of Computer Science and Engineering, C.V. Raman Global University, Bhubaneswar, Odisha, India
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Santosh Kumar Sharma,

Roles Conceptualization, Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Computer Science and Engineering, C.V. Raman Global University, Bhubaneswar, Odisha, India
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Sujata Dash ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: smallik@arizona.edu, sauravmtech2@gmail.com (SM); sujata238dash@gmail.com (SD)

Affiliation Department of Information Technology, School of Engineering and Technology, Nagaland University, Meriema, Nagaland, India
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Bernardo Lemos,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Validation, Writing – review & editing

Affiliations Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona, United States of America
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Saurav Mallik

Roles Conceptualization, Data curation, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: smallik@arizona.edu, sauravmtech2@gmail.com (SM); sujata238dash@gmail.com (SD)

Affiliations Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona, United States of America

https://orcid.org/0000-0003-4107-6784

⨯

Explainable AI-driven diagnosis model for early glaucoma detection using grey-wolf optimized extreme learning machine approach

Debendra Muduli,
Santosh Kumar Sharma,
Sujata Dash,
Bernardo Lemos,
Saurav Mallik

Published: May 4, 2026
https://doi.org/10.1371/journal.pcbi.1013139

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Glaucoma
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Machine learning
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Machine learning algorithms
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Imaging techniques
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Optimization
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Wolves
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Linear discriminant analysis
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