Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution

• Harriet Longley,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0009-0005-7413-5869

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• Christophe Fraser,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Chris Wymant,

  Roles Methodology, Writing – review & editing

  Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Katrina Lythgoe

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  * E-mail: katrina.lythgoe@biology.ox.ac.uk

  Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Biology, University of Oxford, Oxford, United Kingdom

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