GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

Emre Baspinar; Martina Simonti; Hadi Srour; Mathieu Desroches; Daniele Avitabile; Massimo Mantegazza

doi:10.1371/journal.pcbi.1013099

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Open Access

Peer-reviewed

Research Article

GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

Emre Baspinar ,

Roles Conceptualization, Formal analysis, Investigation, Software, Validation, Writing – original draft, Writing – review & editing

* E-mail: emre.baspinar@inria.fr (EB), d.avitabile@vu.nl (DA), mantegazza@ipmc.cnrs.fr (MM)

Affiliations MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France, Université de Montpellier, Montpellier, France

https://orcid.org/0000-0002-9518-3705

⨯
Martina Simonti,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Université Côte d’Azur, Valbonne-Sophia Antipolis, France, CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, Inserm U1323, Valbonne-Sophia Antipolis, France
⨯
Hadi Srour,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliations Université Côte d’Azur, Valbonne-Sophia Antipolis, France, CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, Inserm U1323, Valbonne-Sophia Antipolis, France
⨯
Mathieu Desroches,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France, Université de Montpellier, Montpellier, France, MCEN Team, Basque Center for Applied Mathematics, Bilbao, Spain
⨯
Daniele Avitabile ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

* E-mail: emre.baspinar@inria.fr (EB), d.avitabile@vu.nl (DA), mantegazza@ipmc.cnrs.fr (MM)

Affiliations MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France, Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, Amsterdam Neuroscience - System and Network Neuroscience, Amsterdam, The Netherlands
⨯
Massimo Mantegazza

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: emre.baspinar@inria.fr (EB), d.avitabile@vu.nl (DA), mantegazza@ipmc.cnrs.fr (MM)

Affiliations Université Côte d’Azur, Valbonne-Sophia Antipolis, France, CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, Inserm U1323, Valbonne-Sophia Antipolis, France

https://orcid.org/0000-0002-1070-7929

⨯

GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

Emre Baspinar,
Martina Simonti,
Hadi Srour,
Mathieu Desroches,
Daniele Avitabile,
Massimo Mantegazza

Published: June 4, 2025
https://doi.org/10.1371/journal.pcbi.1013099

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