A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Sofia Farina; Alessandro Cattabiani; Darshan Mandge; Polina Shichkova; James B. Isbister; Jean Jacquemier; James G. King; Henry Markram; Daniel Keller

doi:10.1371/journal.pcbi.1013070

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Open Access

Peer-reviewed

Research Article

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Sofia Farina ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

* E-mail: sofia.farina@outlook.com (SF)

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland

https://orcid.org/0000-0001-6638-9811

⨯
Alessandro Cattabiani,

Roles Data curation, Methodology, Software, Visualization, Writing – original draft

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland
⨯
Darshan Mandge,

Roles Data curation, Methodology, Writing – original draft

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland

https://orcid.org/0000-0002-7104-4604

⨯
Polina Shichkova,

Roles Conceptualization, Methodology, Software, Validation, Writing – review & editing

Affiliations Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland, Biognosys AG, Schlieren, Switzerland

https://orcid.org/0000-0002-2574-1732

⨯
James B. Isbister,

Roles Methodology, Writing – review & editing

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland
⨯
Jean Jacquemier,

Roles Data curation, Writing – review & editing

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland
⨯
James G. King,

Roles Resources, Supervision

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland
⨯
Henry Markram,

Roles Conceptualization, Funding acquisition, Resources

Affiliations Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland, Brain Mind Institute, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
⨯
Daniel Keller

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Geneva, Switzerland

https://orcid.org/0000-0003-3280-6255

⨯

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Sofia Farina,
Alessandro Cattabiani,
Darshan Mandge,
Polina Shichkova,
James B. Isbister,
Jean Jacquemier,
James G. King,
Henry Markram,
Daniel Keller

Published: May 20, 2025
https://doi.org/10.1371/journal.pcbi.1013070

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