Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings

Yann-Stanislas H. M. Barral; Liudmila Polonchuk; Michael Clerx; David J. Gavaghan; Gary R. Mirams; Ken Wang

doi:10.1371/journal.pcbi.1012913

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Open Access

Peer-reviewed

Research Article

Comparison of in silico predictions of action potential duration in response to inhibition of I_Kr and I_CaL with new human ex vivo recordings

Yann-Stanislas H. M. Barral ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: yann-stanislas.barral@roche.com

Affiliations Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland, Department of Computer Science, University of Oxford, Oxford, United Kingdom

https://orcid.org/0009-0004-2268-5669

⨯
Liudmila Polonchuk,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
⨯
Michael Clerx,

Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
David J. Gavaghan,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Department of Computer Science, University of Oxford, Oxford, United Kingdom
⨯
Gary R. Mirams,

Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0002-4569-4312

⨯
Ken Wang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
⨯

Comparison of in silico predictions of action potential duration in response to inhibition of I_Kr and I_CaL with new human ex vivo recordings

Yann-Stanislas H. M. Barral,
Liudmila Polonchuk,
Michael Clerx,
David J. Gavaghan,
Gary R. Mirams,
Ken Wang

Published: July 7, 2025
https://doi.org/10.1371/journal.pcbi.1012913

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Ionic current
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Action potentials
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Medical risk factors
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Ion channels
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