Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins

• Guihua Wang ,

  Contributed equally to this work with: Guihua Wang, Dan Zhang, Zhifeng He

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Dan Zhang ,

  Contributed equally to this work with: Guihua Wang, Dan Zhang, Zhifeng He

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Zhifeng He ,

  Contributed equally to this work with: Guihua Wang, Dan Zhang, Zhifeng He

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Bin Mao,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Xiao Hu,

  Roles Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Li Chen,

  Roles Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Biosafety Laboratory of West China Hospital, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Qingxin Yang,

  Roles Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Biosafety Laboratory of West China Hospital, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Zhen Zhou,

  Roles Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yating Zhang,

  Roles Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Kepan Linghu,

  Roles Methodology, Resources, Software

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Chao Tang,

  Roles Funding acquisition, Resources, Software

  Affiliation Biosafety Laboratory of West China Hospital, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  ⨯
• Zijie Xu,

  Roles Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Defu Liu,

  Roles Software, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Junwei Song,

  Roles Software, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Huiying Wang,

  Roles Software, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

  ⨯
• Yishan Lin,

  Roles Software, Writing – original draft

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Ruihan Li,

  Roles Software

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jing-Wen Lin ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lin.jingwen@scu.edu.cn (JWL); luchen@scu.edu.cn (LC)

  Affiliation Biosafety Laboratory of West China Hospital, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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•  [ ... ],
• Lu Chen

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lin.jingwen@scu.edu.cn (JWL); luchen@scu.edu.cn (LC)

  Affiliation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0002-1083-9729

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