Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods

• Wei-Yu Lin,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom

  https://orcid.org/0000-0002-9267-7988

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• Melissa Kartawinata,

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom, Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom

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• Bethany R. Jebson,

  Roles Data curation, Investigation

  Affiliations Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom, Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom

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• Restuadi Restuadi,

  Roles Investigation

  Affiliations Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom, Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom

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• Hannah Peckham,

  Roles Data curation, Investigation

  Affiliations Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom, Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom

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• Anna Radziszewska,

  Roles Data curation, Investigation

  Affiliations Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom, Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom

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• Claire T. Deakin,

  Roles Conceptualization, Supervision

  Affiliations Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom, Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom, National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom

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• Coziana Ciurtin,

  Roles Conceptualization, Supervision

  Affiliations Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom, Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom

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• CLUSTER Consortium ,

  ¶Membership of [CLUSTER Consortium] is provided in the Acknowledgements.

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• Lucy R. Wedderburn,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliations Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom, Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom, National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom

  https://orcid.org/0000-0002-7495-1429

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• Chris Wallace

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cew54@cam.ac.uk

  Affiliations MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom, Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0001-9755-1703

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