Neural network approaches, including use of topological data analysis, enhance classification of human induced pluripotent stem cell colonies by treatment condition

Alexander Ruys de Perez; Paul E. Anderson; Elena S. Dimitrova; Melissa L. Kemp

doi:10.1371/journal.pcbi.1012801

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Peer-reviewed

Research Article

Neural network approaches, including use of topological data analysis, enhance classification of human induced pluripotent stem cell colonies by treatment condition

Alexander Ruys de Perez ,

Contributed equally to this work with: Alexander Ruys de Perez, Elena S. Dimitrova, Melissa L. Kemp

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: aruysdep@calpoly.edu

Affiliations Mathematics Department, Bailey College of Science and Mathematics, California Polytechnic State University - San Luis Obispo, San Luis Obispo, California, United States of America, School of Mathematics, Georgia Institute of Technology, Atlanta, Georgia, United States of America

https://orcid.org/0000-0002-8563-236X

⨯
Paul E. Anderson,

Roles Software, Supervision, Validation, Writing – review & editing

Affiliation Department of Computer Science and Software Engineering, College of Engineering, California Polytechnic State University - San Luis Obispo, San Luis Obispo, California, United States of America
⨯
Elena S. Dimitrova ,

Contributed equally to this work with: Alexander Ruys de Perez, Elena S. Dimitrova, Melissa L. Kemp

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Mathematics Department, Bailey College of Science and Mathematics, California Polytechnic State University - San Luis Obispo, San Luis Obispo, California, United States of America
⨯
Melissa L. Kemp

Contributed equally to this work with: Alexander Ruys de Perez, Elena S. Dimitrova, Melissa L. Kemp

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America

https://orcid.org/0000-0003-3781-8802

⨯

Neural network approaches, including use of topological data analysis, enhance classification of human induced pluripotent stem cell colonies by treatment condition

Alexander Ruys de Perez,
Paul E. Anderson,
Elena S. Dimitrova,
Melissa L. Kemp

Published: July 11, 2025
https://doi.org/10.1371/journal.pcbi.1012801

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