Learning predictive signatures of HLA type from T-cell repertoires

María Ruiz Ortega; Mikhail V. Pogorelyy; Anastasia A. Minervina; Paul G. Thomas; Thierry Mora; Aleksandra M. Walczak

doi:10.1371/journal.pcbi.1012724

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Open Access

Peer-reviewed

Research Article

Learning predictive signatures of HLA type from T-cell repertoires

María Ruiz Ortega,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratoire de physique de l’École Normale Supérieure, CNRS, PSL Université, Sorbonne Université, and Université Paris-Cité, Paris, France
⨯
Mikhail V. Pogorelyy,

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

Affiliation Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Anastasia A. Minervina,

Roles Conceptualization, Data curation, Validation, Writing – review & editing

Affiliation Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Paul G. Thomas,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Thierry Mora ,

Contributed equally to this work with: Thierry Mora, Aleksandra M. Walczak

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: thierry.mora@phys.ens.fr (TM); aleksandra.walczak@phys.ens.fr (AMW)

Affiliation Laboratoire de physique de l’École Normale Supérieure, CNRS, PSL Université, Sorbonne Université, and Université Paris-Cité, Paris, France

https://orcid.org/0000-0002-5456-9361

⨯
Aleksandra M. Walczak

Contributed equally to this work with: Thierry Mora, Aleksandra M. Walczak

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: thierry.mora@phys.ens.fr (TM); aleksandra.walczak@phys.ens.fr (AMW)

Affiliation Laboratoire de physique de l’École Normale Supérieure, CNRS, PSL Université, Sorbonne Université, and Université Paris-Cité, Paris, France
⨯

Learning predictive signatures of HLA type from T-cell repertoires

María Ruiz Ortega,
Mikhail V. Pogorelyy,
Anastasia A. Minervina,
Paul G. Thomas,
Thierry Mora,
Aleksandra M. Walczak

Published: January 6, 2025
https://doi.org/10.1371/journal.pcbi.1012724

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T cell receptors
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Major histocompatibility complex
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Cytotoxic T cells
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Protein sequencing
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Cloning
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DNA recombination
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