Deciphering the interplay between biology and physics with a finite element method-implemented vertex organoid model: A tool for the mechanical analysis of cell behavior on a spherical organoid shell

• Julien Laussu ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: julien.laussu@gmail.com (JL); florian.bugarin@univ-tlse3.fr (FB); audrey.ferrand@inserm.fr (AF)

  Affiliations Institut Clément Ader, Université Fédérale de Toulouse Midi-Pyrénées, Institut Clément Ader–CNRS UMR 5312 –UPS/INSA/Mines Albi/ISAE, Toulouse, France, IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

  https://orcid.org/0000-0002-0110-9388

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• Deborah Michel,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

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• Léa Magne,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Institut Clément Ader, Université Fédérale de Toulouse Midi-Pyrénées, Institut Clément Ader–CNRS UMR 5312 –UPS/INSA/Mines Albi/ISAE, Toulouse, France, IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

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• Stephane Segonds,

  Roles Conceptualization, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institut Clément Ader, Université Fédérale de Toulouse Midi-Pyrénées, Institut Clément Ader–CNRS UMR 5312 –UPS/INSA/Mines Albi/ISAE, Toulouse, France

  https://orcid.org/0000-0003-2462-9842

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• Steven Marguet,

  Roles Formal analysis, Methodology, Validation

  Affiliation Institut Clément Ader, Université Fédérale de Toulouse Midi-Pyrénées, Institut Clément Ader–CNRS UMR 5312 –UPS/INSA/Mines Albi/ISAE, Toulouse, France

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• Dimitri Hamel,

  Roles Investigation, Methodology

  Affiliation IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

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• Muriel Quaranta-Nicaise,

  Roles Investigation, Methodology

  Affiliation IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

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• Frederick Barreau,

  Roles Funding acquisition

  Affiliation IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

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• Emmanuel Mas,

  Roles Resources

  Affiliations IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France, Gastroenterology, Hepatology, Nutrition, Diabetology and Hereditary Metabolic Diseases Unit, Hôpital des Enfants, CHU de Toulouse, Toulouse, France

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• Vincent Velay,

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliation Institut Clément Ader (ICA), Université de Toulouse, CNRS, IMT Mines Albi, INSA, ISAE-SUPAERO, UPS, Campus Jarlard, Albi, France

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• Florian Bugarin ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: julien.laussu@gmail.com (JL); florian.bugarin@univ-tlse3.fr (FB); audrey.ferrand@inserm.fr (AF)

  Affiliation Institut Clément Ader, Université Fédérale de Toulouse Midi-Pyrénées, Institut Clément Ader–CNRS UMR 5312 –UPS/INSA/Mines Albi/ISAE, Toulouse, France

  https://orcid.org/0000-0001-5637-5504

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• Audrey Ferrand

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: julien.laussu@gmail.com (JL); florian.bugarin@univ-tlse3.fr (FB); audrey.ferrand@inserm.fr (AF)

  Affiliation IRSD—Institut de Recherche en Santé Digestive, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

  https://orcid.org/0000-0002-1057-8151

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