Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers

• Kwang Su Kim ,

  Contributed equally to this work with: Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Department of Scientific Computing, Pukyong National University, Busan, South Korea

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• Masashi Iwamoto ,

  Contributed equally to this work with: Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Kosaku Kitagawa ,

  Contributed equally to this work with: Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Hyeongki Park,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Sanae Hayashi,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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• Senko Tsukuda,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Takeshi Matsui,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan

  https://orcid.org/0000-0003-4740-1824

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• Masanori Atsukawa,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan

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• Kentaro Matsuura,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan

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• Natthaya Chuaypen,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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• Pisit Tangkijvanich,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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• Lena Allweiss,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliations Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems partner sites, Germany

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• Takara Nishiyama,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Naotoshi Nakamura,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0002-4798-3660

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• Yasuhisa Fujita,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Eiryo Kawakami,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, Medical Sciences Innovation Hub Program; RIKEN, Yokohama, Kanagawa, Japan

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• Shinji Nakaoka,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

  ⨯
• Masamichi Muramatsu,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Kazuyuki Aihara,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan

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• Takaji Wakita,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Alan S. Perelson,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0002-2455-0002

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• Maura Dandri,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliations Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Koichi Watashi ,

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  * E-mail: kwatashi@niid.go.jp (KW); iwami.iblab@bio.nagoya-u.ac.jp (SI)

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Sciences, Faculty of Science and Technology, Tokyo University of Sciences, Chiba, Japan

  https://orcid.org/0000-0002-4536-9966

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• Shingo Iwami ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: kwatashi@niid.go.jp (KW); iwami.iblab@bio.nagoya-u.ac.jp (SI)

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan, Institute of Mathematics for Industry, Kyushu University,; Fukuoka, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Wako, Japan, Science Groove Inc., Fukuoka, Japan

  https://orcid.org/0000-0002-1780-350X

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•  [ ... ],
• Yasuhito Tanaka

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

  https://orcid.org/0000-0002-2473-6966

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