Quantitative evaluation of DNA damage repair dynamics to elucidate predictors of autism vs. cancer in individuals with germline PTEN variants

• Ruipeng Wei,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Nutrition and Systems Biology and Bioinformatics Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-6056-222X

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• Masahiro Hitomi,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Tammy Sadler,

  Roles Data curation, Investigation, Project administration, Validation

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Lamis Yehia,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Daniela Calvetti,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Department of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University College of Arts and Sciences, Cleveland, Ohio, United States of America

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• Jacob Scott ,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: scottj10@ccf.org

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio, United States of America, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-2971-7673

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• Charis Eng

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Center for Personalized Genetic Healthcare, Medical Specialties Institute, Cleveland Clinic, United States of America, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Germline High Risk Cancer Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America

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