An exploration into CTEPH medications: Combining natural language processing, embedding learning, in vitro models, and real-world evidence for drug repurposing

• Daniel Steiert ,

  Contributed equally to this work with: Daniel Steiert, Corey Wittig

  Roles Conceptualization, Data curation, Formal analysis, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of in vitro modeling systems of pulmonary and thrombotic diseases, Institute of Physiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

  https://orcid.org/0000-0003-1666-5691

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• Corey Wittig ,

  Contributed equally to this work with: Daniel Steiert, Corey Wittig

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of in vitro modeling systems of pulmonary and thrombotic diseases, Institute of Physiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

  https://orcid.org/0000-0003-4296-9293

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• Priyanka Banerjee,

  Roles Formal analysis, Writing – review & editing

  Affiliation Structural Bioinformatics Group, Institute of Physiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Robert Preissner,

  Roles Formal analysis, Writing – review & editing

  Affiliation Structural Bioinformatics Group, Institute of Physiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

  https://orcid.org/0000-0002-2407-1087

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• Robert Szulcek

  Roles Conceptualization, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: robert.szulcek@charite.de

  Affiliations Laboratory of in vitro modeling systems of pulmonary and thrombotic diseases, Institute of Physiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Deutsches Herzzentrum der Charité, Department of Cardiac Anesthesiology and Intensive Care Medicine, Berlin, Germany

  https://orcid.org/0000-0003-0450-7338

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