Identification of a serum proteomic biomarker panel using diagnosis specific ensemble learning and symptoms for early pancreatic cancer detection

• Alexander Ney ,

  Contributed equally to this work with: Alexander Ney, Nuno R. Nené

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: alexney@me.com (AN); nuno.nene.10@ucl.ac.uk (NRN); stephen.pereira@ucl.ac.uk (SPP)

  Affiliation Institute for Liver and Digestive Health, University College London, London, United Kingdom

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• Nuno R. Nené ,

  Contributed equally to this work with: Alexander Ney, Nuno R. Nené

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alexney@me.com (AN); nuno.nene.10@ucl.ac.uk (NRN); stephen.pereira@ucl.ac.uk (SPP)

  Affiliations Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, United Kingdom, Cancer Institute, University College London, London, United Kingdom, Department of Statistical Science, University College London, London, United Kingdom

  https://orcid.org/0000-0002-4275-0649

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• Eva Sedlak,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, United Kingdom

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• Pilar Acedo,

  Roles Writing – review & editing

  Affiliation Institute for Liver and Digestive Health, University College London, London, United Kingdom

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• Oleg Blyuss,

  Roles Writing – review & editing

  Affiliations Center for Cancer Prevention, Detection and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom, Department of Pediatrics and Pediatric Infectious Diseases, Institute of Child´s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

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• Harry J. Whitwell,

  Roles Writing – review & editing

  Affiliations Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, United Kingdom, National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, IRDB, Building Imperial College London, London, United Kingdom, Section of Bioanalytical Chemistry, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Sir Alexander Fleming Building, Imperial College London, London, United Kingdom

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• Eithne Costello,

  Roles Writing – review & editing

  Affiliation Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom

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• Aleksandra Gentry-Maharaj,

  Roles Writing – review & editing

  Affiliations Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, United Kingdom, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom

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• Norman R. Williams,

  Roles Writing – review & editing

  Affiliation Division of Surgery & Interventional Science, University College London, London, United Kingdom

  https://orcid.org/0000-0001-6496-312X

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• Usha Menon,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom

  https://orcid.org/0000-0003-3708-1732

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• Giuseppe K. Fusai,

  Roles Writing – review & editing

  Affiliation HPB & Liver Transplant Unit, Royal Free London, London, United Kingdom

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• Alexey Zaikin,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, United Kingdom, Institute for Cognitive Neuroscience, University Higher School of Economics, Moscow, Russia, Department of Mathematics, University College London, London, United Kingdom, Centre for Cognition and Decision making, Institute for Cognitive Neuroscience, HSE University, Moscow, Russia, Life Improvement by Future Technologies (LIFT) Center, Skolkovo, Moscow, Russia

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• Stephen P. Pereira

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: alexney@me.com (AN); nuno.nene.10@ucl.ac.uk (NRN); stephen.pereira@ucl.ac.uk (SPP)

  Affiliation Institute for Liver and Digestive Health, University College London, London, United Kingdom

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