Overcoming CRISPR-Cas9 off-target prediction hurdles: A novel approach with ESB rebalancing strategy and CRISPR-MCA model

• Yanpeng Yang ,

  Contributed equally to this work with: Yanpeng Yang, Yanyi Zheng

  Roles Conceptualization, Data curation, Methodology, Validation, Writing – original draft

  Affiliation School of Mathematics and Computer science, Zhejiang A&F University, Hangzhou, China

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• Yanyi Zheng ,

  Contributed equally to this work with: Yanpeng Yang, Yanyi Zheng

  Roles Conceptualization, Data curation, Project administration

  Affiliation College of Landscape Architecture, Beijing Forestry University, Beijing, China

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• Quan Zou,

  Roles Project administration, Validation, Visualization

  Affiliations Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China, Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China

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• Jian Li ,

  Roles Methodology, Resources, Writing – review & editing

  * E-mail: lijian0120@foxmail.com (JL); hlfeng@zafu.edu.cn (HF)

  Affiliation School of Mathematics and Computer science, Zhejiang A&F University, Hangzhou, China

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• Hailin Feng

  Roles Funding acquisition, Resources, Supervision

  * E-mail: lijian0120@foxmail.com (JL); hlfeng@zafu.edu.cn (HF)

  Affiliation School of Mathematics and Computer science, Zhejiang A&F University, Hangzhou, China

  https://orcid.org/0000-0003-2734-480X

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