Agent-based model predicts that layered structure and 3D movement work synergistically to reduce bacterial load in 3D in vitro models of tuberculosis granuloma

• Alexa Petrucciani,

  Roles Software, Visualization, Writing – original draft

  Affiliation Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America

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• Alexis Hoerter,

  Roles Software, Writing – review & editing

  Affiliation Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America

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• Leigh Kotze,

  Roles Data curation, Writing – review & editing

  Affiliation DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South Africa

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• Nelita Du Plessis,

  Roles Supervision, Writing – review & editing

  Affiliation DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South Africa

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• Elsje Pienaar

  Roles Conceptualization, Writing – review & editing

  * E-mail: epienaar@purdue.edu

  Affiliations Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America, Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, Indiana, United States of America

  https://orcid.org/0000-0002-5408-8795

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