Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics

• Roberth Anthony Rojas Chávez,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, United States of America

  https://orcid.org/0000-0002-7023-2718

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• Mohammad Fili,

  Roles Conceptualization, Formal analysis, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Industrial and Manufacturing Systems Engineering, Iowa State University, Ames, Iowa, United States of America

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• Changze Han,

  Roles Software, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, United States of America

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• Syed A. Rahman,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Isaiah G. L. Bicar,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, United States of America

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• Sullivan Gregory,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, United States of America

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• Annika Helverson,

  Roles Software, Writing – review & editing

  Affiliation Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa, United States of America

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• Guiping Hu,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Industrial and Manufacturing Systems Engineering, Iowa State University, Ames, Iowa, United States of America

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• Benjamin W. Darbro,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States of America

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• Jishnu Das,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Grant D. Brown,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa, United States of America

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• Hillel Haim

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Hillel-haim@uiowa.edu

  Affiliation Department of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, United States of America

  https://orcid.org/0000-0002-6071-5089

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