Beyond homogeneity: Assessing the validity of the Michaelis–Menten rate law in spatially heterogeneous environments

Seolah Shin; Seok Joo Chae; Seunggyu Lee; Jae Kyoung Kim

doi:10.1371/journal.pcbi.1012205

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Open Access

Peer-reviewed

Research Article

Beyond homogeneity: Assessing the validity of the Michaelis–Menten rate law in spatially heterogeneous environments

Seolah Shin ,

Contributed equally to this work with: Seolah Shin, Seok Joo Chae

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Applied Mathematics, Korea University, Sejong, Republic of Korea, Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea
⨯
Seok Joo Chae ,

Contributed equally to this work with: Seolah Shin, Seok Joo Chae

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea
⨯
Seunggyu Lee ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: s.lee:sky509@korea.ac.kr (SL); jk.kim:jaekkim@kaist.ac.kr (JKK)

Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Division of Applied Mathematical Sciences, Korea University, Sejong, Republic of Korea

https://orcid.org/0000-0003-3141-6968

⨯
Jae Kyoung Kim

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: s.lee:sky509@korea.ac.kr (SL); jk.kim:jaekkim@kaist.ac.kr (JKK)

Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea

https://orcid.org/0000-0001-7842-2172

⨯

Beyond homogeneity: Assessing the validity of the Michaelis–Menten rate law in spatially heterogeneous environments

Seolah Shin,
Seok Joo Chae,
Seunggyu Lee,
Jae Kyoung Kim

Published: June 6, 2024
https://doi.org/10.1371/journal.pcbi.1012205

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