Prioritizing drug targets by perturbing biological network response functions

Matthew C. Perrone; Michael G. Lerner; Matthew Dunworth; Andrew J. Ewald; Joel S. Bader

doi:10.1371/journal.pcbi.1012195

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Peer-reviewed

Research Article

Prioritizing drug targets by perturbing biological network response functions

Matthew C. Perrone,

Roles Conceptualization, Formal analysis, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

https://orcid.org/0000-0002-3720-212X

⨯
Michael G. Lerner,

Roles Conceptualization, Formal analysis, Funding acquisition, Software, Supervision, Writing – review & editing

Affiliation Department of Physics, Engineering and Astronomy, Earlham College, Richmond, Indiana, United States of America
⨯
Matthew Dunworth,

Roles Validation, Visualization, Writing – review & editing

Affiliation Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Andrew J. Ewald,

Roles Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

Affiliations Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America, Giovanis Institute for Translational Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Joel S. Bader

Roles Conceptualization, Formal analysis, Funding acquisition, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: joel.bader@jhu.edu

Affiliations Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America, Giovanis Institute for Translational Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

https://orcid.org/0000-0002-6020-4625

⨯

Prioritizing drug targets by perturbing biological network response functions

Matthew C. Perrone,
Michael G. Lerner,
Matthew Dunworth,
Andrew J. Ewald,
Joel S. Bader

Published: June 27, 2024
https://doi.org/10.1371/journal.pcbi.1012195

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