Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity

• Magnus Pirovino,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation OPIRO Consulting Ltd., Triesen, Principality of Liechtenstein

  ⨯
• Christian Iseli,

  Roles Methodology, Software, Validation, Visualization

  Affiliation Bioinformatics Competence Center, EPFL and Unil, Lausanne, Switzerland

  https://orcid.org/0000-0002-2296-2863

  ⨯
• Joseph A. Curran,

  Roles Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Molecular Medicine, and Institute of Genetics and Genomics of Geneva (iGE3), Geneva University, Genève, Switzerland

  ⨯
• Bernard Conrad

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bernard.conrad@genesupport.ch

  Affiliation Genesupport, Avenue de Sévelin 18, Lausanne, Switzerland

  https://orcid.org/0000-0002-3662-9041

  ⨯